Which is a common side effect of spironolactone therapy for hyperaldosteronism?

Which is a common side effect of spironolactone therapy for hyperaldosteronism?

• A. Urticaria
• B. Nausea
• C. Hyperkalemia
• D. Dizziness

Answer: (A)

Spironolactone is a potassium-sparing diuretic that blocks the effects of aldosterone in the collecting ducts, which reduces sodium reabsorption and potassium loss in the urine. Because it decreases potassium excretion, it commonly causes hyperkalemia, a clinically important side effect, especially in those with kidney impairment or when used with other potassium-raising medications. Urticaria or rash can occur as an allergic reaction, but they are not the typical or most frequent side effects. Nausea and dizziness can happen but do not reflect the main risk associated with this therapy.

Spironolactone is a potassium-sparing diuretic that blocks the effects of aldosterone in the collecting ducts, which reduces sodium reabsorption and potassium loss in the urine. Because it decreases potassium excretion, it commonly causes hyperkalemia, a clinically important side effect, especially in those with kidney impairment or when used with other potassium-raising medications. Urticaria or rash can occur as an allergic reaction, but they are not the typical or most frequent side effects. Nausea and dizziness can happen but do not reflect the main risk associated with this therapy.