In a patient with suspected hyperaldosteronism, which laboratory finding would you expect?

In a patient with suspected hyperaldosteronism, which laboratory finding would you expect?

• A. Decreased blood pH
• B. Elevated blood pH
• C. Normal blood pH
• D. Unchanged pH

Answer: (B)

Excess aldosterone in primary hyperaldosteronism drives more hydrogen ion (and potassium) secretion in the distal nephron, leading to a metabolic alkalosis. That means the blood becomes more alkaline, so an elevated blood pH is expected. You’d also typically see hypokalemia and a high bicarbonate level with low renin activity. Decreased pH would suggest metabolic acidosis, while normal or unchanged pH would not reflect the alkalosis caused by aldosterone excess.

Excess aldosterone in primary hyperaldosteronism drives more hydrogen ion (and potassium) secretion in the distal nephron, leading to a metabolic alkalosis. That means the blood becomes more alkaline, so an elevated blood pH is expected. You’d also typically see hypokalemia and a high bicarbonate level with low renin activity. Decreased pH would suggest metabolic acidosis, while normal or unchanged pH would not reflect the alkalosis caused by aldosterone excess.